Hairloss Study Abstract: Casodex (ICI 176,334)--a new, pure, peripherally-selective anti-androgen: preclinical studies.

Title: "Casodex" (ICI 176,334)--a new, pure, peripherally-selective anti-androgen: preclinical studies.
Title Abreviation: Horm Res		Date of Pub: 1989
Author: Furr BJ;
Issue/Part/Supplement: -HEADING-	Volume Issue: 32 Suppl 1		Pagination: 69-76
MESH Headings: Androgen Antagonists (PD/PK/TU); Anilides (PD/PK/TU); Animal; Cyproterone (AA/TU); Dogs; Flutamide (TU); Imidazoles (TU); Male; Prostatic Neoplasms (*DT); Rats; -RN-;
Journal Title Code: GBI	Publication Type: JOURNAL ARTICLE
Date of Entry: 900315N	Entry Month: 9005
Country: SWITZERLAND	Index Priority: 2
Language: Eng	Unique Identifier: 90128934
Unique Identifier: 90128934	ISSN: 0301-0163
Abstract: The relative merits of the steroidal anti-androgen, cyproterone acetate, and the non-steroidal anti-androgens flutamide and nilutamide, are reviewed. It is concluded that pure anti-androgens offer some advantages over cyproterone acetate but that they each have some features which merit improvement. A new compound which was a pure anti-androgen, peripherally selective, well tolerated with a long half-life would have significant advantages. Preclinical studies in rats and dogs show that Casodex (ICI 176,334) is a potent pure anti-androgen which is well tolerated and has a long half-life. Casodex induces marked regression of the prostate yet fails to cause the substantial elevation in serum LH and testosterone seen with flutamide and nilutamide; it is thus peripherally selective. Casodex is as effective as surgical or medical castration with Zoladex in limiting the growth of the transplantable androgen-responsive Dunning rat prostate tumour. Such a profile makes Casodex a strong candidate as the future anti-androgen of choice for the treatment of prostate cancer and benign prostate hypertrophy.
Abstract By: Author
Address: Bioscience I, ICI Pharmaceuticals, Macclesfield, Cheshire, UK.

Our Sponsors »

Order Propecia, Spectral DNC or Avodart online today from hair2go.com!

Is your natural treatment working for you? Or even working at all?
Advertorial
Why many natural oral supplements for hair loss have little effect on hair loss and why others do.