Title: [Pyridyl-substituted tetralone derivatives: a new class of nonsteroidal aromatase inhibitors]
Title Abreviation: Arch Pharm (Weinheim) Date of Pub: 1991 Oct
Author: Bayer H; Hartmann RW;
Issue/Part/Supplement: 10 Volume Issue: 324 Pagination: 815-20
MESH Headings: Aromatase (*AI); Cholesterol Desmolase (AI); English Abstract; Pyridines (*CS/PD); Tetrahydronaphthalenes (*CS/PD); -RN-;
Journal Title Code: 8AC Publication Type: JOURNAL ARTICLE
Date of Entry: 920506N Entry Month: 9207
Country: GERMANY Index Priority: 3
Language: Ger Unique Identifier: 92215096
Unique Identifier: 92215096 ISSN: 0365-6233
Abstract: Structural modification of flavone and flavaNone, two weak inhibitors of aromatase, led to the new compounds 1-7, the syntheses of which are described as well as the evaluation of their aromatase and desmolase inhibitory potency. With the exception of 2 all compounds show a stronger inhibition of aromatase than the parent compounds and are more effective inhibitors than aminoglutethimide (AG), the only commercially available compound. In contrast to AG compounds 1 and 3-7 exhibit no desmolase inhibitory activity. In case of AG this effect leads to undesirable side effects.
Abstract By: Author
Address: Fachrichtung Pharmazeutische Chemie, Universität des Saarlandes.
Transliterated/Vernacular Title: Pyridyl-substituierte Tetralonderivate: Eine neue Klasse nichtsteroidaler Aromatase-Inhibitoren.

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