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Hairloss Study Abstract: Photostability profiles of minoxidil solutions.

Title: Photostability profiles of minoxidil solutions.
Title Abreviation: PDA J Pharm Sci Technol		Date of Pub: 1996 Mar-Apr
Author: Chinnian D; Asker AF;
Issue/Part/Supplement: 2	Volume Issue: 50		Pagination: 94-8
MESH Headings: Antihypertensive Agents*; Buffers*; Drug Stability*; Light*; Minoxidil*; Osmolar Concentration*; Solutions*; -PG-;
Journal Title Code: B5J	Publication Type: JOURNAL ARTICLE
Date of Entry: 970106N	Entry Month: 9703
Country: UNITED STATES	Index Priority: 3
Language: Eng	Unique Identifier: 97089869
Unique Identifier: 97089869	ISSN: 1079-7440
Abstract: Photostability profiles of minoxidil solutions exposed to fluorescent light, under the influence of several parameters like concentration, pH, buffer species, photostabilizers, container type, solvent system, and skin penetration enhancers were studied. The assay of minoxidil was done spectrophotometrically at 230 nm and 290 nm, using double beam UV-visible spectrophotometer. The results show that photodegradation of minoxidil solutions follows first order rate. Furthermore, minoxidil solution (4.5 micrograms/ml) was found to be more stable in phosphate buffer as compared to acetate buffer. Amber glass offered equivalent photoprotection as aluminum foil-covered glass. Minoxidil was found to be most stable in a solvent system of water or 25% v/v PEG300 and least stable in 25% v/v propylene glycol. Of the penetration enhancers studied dimethyl sulfoxide (DMSO) caused the least photodecomposition of minoxidil. The order of photoprotection of the five potential photostabilizers were as follows: sodium thiosulfate > EDTA > sodium benzoate approximately thiourea > sodium metabisulfite. Varying the concentration of sodium thiosulfate did not affect the minoxidil photostability. The study also indicates that minoxidil solution (4.5 micrograms/ml) is most photostable in pH 8 phosphate buffer. An increase in ionic strength had a photostabilizing effect until an optimum strength of 0.17, then further increase caused the rate of photodegradation to remain unchanged.
Abstract By: Author
Address: College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, USA.