Spectral DNC v Rogaine Foam

Adenosine - 16 pages

http://www.divineskin.com/spectralDNC/ATC+2005_Tajima.pdf

Procyanidin B-2 - 11 pages

http://www.divineskin.com/spectralDNC/ProcyanidinStudy.pdf

Phytomedicine. 2000 Dec;7(6):529-36. Related Articles, Links

Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent.

Kamimura A, Takahashi T, Watanabe Y. Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., Ibaraki, Japan. ayako.kamimura@kyowa.co.jp

Procyanidin B-2 is a polyphenol compound we have identified in apple which acts as a hair-growing factor in the murine model both in vitro and in vivo. This report describes our investigation of the effects of 1% procyanidin B-2 tonic on human hair growth after sequential use for 6 months. A double-blind clinical test involving a total of 29 subjects was performed. Nineteen men in the procyanidin B-2 group and 10 men in the placebo control group were subjected to analyses. No adverse side effects were observed in either group. The hair-growing effect was evaluated using a macrophotography technique combined with measurements of the hair diameter of clipped hairs. The increase in number of total hairs in the designated scalp area (0.5 cm square = 0.25 cm2 area) of procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 6.68 +/- 5.53 (mean +/- SD)/0.25 cm2; placebo, 0.08 +/- 4.56 (mean +/- SD)/0.25 cm2; P < 0.005, two-sample t test). The increase in number of terminal hairs, which are defined as hairs more than 60 microm in diameter, in the designated area (0.5 cm square = 0.25 cm2 area) of the procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 1.99 +/- 2.58 (mean +/- SD)/0.25 cm2; placebo, -0.82 +/- 3.40 (mean +/- SD)/0.25 cm2; P < 0.02, two-sample t test). Procyanidin B-2 therapy shows potential as a safe and promising cure for male pattern baldness.

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Phytother Res. 2001 Jun;15(4):331-6. Related Articles, Links

The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent.

Takahashi T, Kamimura A, Yokoo Y, Honda S, Watanabe Y.

Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., 2, Miyukigaoka, Tsukuba, Ibaraki 305-0841, Japan. tomoya.takahashi@kyowa.co.jp

Procyanidin B-2 is a compound we have identified in apple which acts as a growth-promoting factor on murine hair epithelial cells. This report describes our investigation of the hair-growing effects of 1% procyanidin B-2 tonic after sequential use for 4 months. A double-blind clinical trial was performed, involving a total of 29 subjects (procyanidin B-2, 19 men; placebo, 10 men). No adverse side effects were observed in either group. In the procyanidin B-2 group, 78.9% showed an increased mean value of hair diameter, whereas only 30.0% in the placebo group showed any increase (p < 0.02, Fisher's exact probability test). The increased ratio of hairs measuring more than 40 microm in diameter after 4 months of procyanidin B-2 treatment was significantly higher than that of the placebo controls (p < 0.05, two-sample-t-test). The increase in number of total hairs in the designated scalp area (0.25 cm(2)) of procyanidin B-2 subjects after a 4 month trial was significantly greater than that of the placebo controls (procyanidin-B-2, 3.67 +/- 4.09 (mean +/- SD)/0.25 cm(2); placebo, -2.54 +/- 4.00/0.25 cm(2); p < 0.001, two-sample t-test). Procyanidin B-2 therapy shows potential as a promising cure for male pattern baldness. Copyright 2001 John Wiley & Sons, Ltd.

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Br J Dermatol. 2002 Jan;146(1):41-51. Related Articles, Links

Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study.

Kamimura A, Takahashi T. Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., 2, Miyukigaoka, Tsukuba, Ibaraki 305-0841, Japan. ayako.kamimura@kyowa.co.jp

BACKG

A RANDOMIZED TRIAL OF ADENOSINE IN ANDROGENETIC ALOPECIA

Yasushi Watanabe, Kelshi Nagashima, Noriro Hanzawa, Masashl Ogo, Akihlro Ishino, Yosuke Nakazawa, Masaaki Uemura, and Masahiro Tajima

Watanabe Dermatological clinic, Tokyo, Shinjuku Biru Clinic, Tokyo, Shiseido Science division, Tokyo and Shiseido Research Center, Yokohama, Japan

Objective: Adenosine up-regulates the expression of fibroblast growth factor 7 (FGF7) and vascular endothelial growth factor (VEGF) on cultured dermal papilla cells via adenosine receptors. We therefore speculated that adenosine stimulates growth of hair fiber due to the action of FGF7 and VEGF for epithelial cells in hair follicles. In this study,we performed a clinical trial to investigate the efficacy and safety of adenosine in hairloss associated with androgenetic alopecia (AGA).

Methods: Ahundred and four volunteers with AGAwere registered In a randomized double-blind trial that used an adenosine (0.7S%) topical lotion or niacin amide (0.1%)topical lotion twice daily for 6 months. Efficacy was evaluated by investigator assessments of change in global scalp coverage, change in the ratio of veilus-like(under 40 micrometers in diameter) and thick hairs (not less 60 micrometers or 80 micrometers in diameter), and hair density, in vertex.

Results: Fifty-one of 52 adenosine-treated subjects and 50 of 52 niacin amide-treated subjects completed the 6-month study. For global improvement, adenosine was significantly superior to niacin amide. Treatment with either lotion resulted in a significantlydecreased ratio of vellus- like hair and also significantly increased the ratio of thick hair, but did not change hair density. Regarding the Increase in the ratio of thick hair, adenosine was significantly superior to niacin amide. Adverse effects were not found.

Conclusion: In men with AGA,adenosine increased hair growth and thickened vellus-like hair without side effects. It would appear that the efficacy of hair growth results from the effects of FGF7 and VEGF which are stimulated by activation of adenosine receptors on dermal papilla cells.

1.....The new Rogaine Foam grew 65.88% more hair than the original 5% version at the 16 week point in clinical trials (56% growth,original v 85% growth,foam)

2.....The new foam was developed in conjunction with Connetics using their Versafoam technology

3.....The new foam has *reduced* propylene glycol, that often caused irritation and hypersensitivity to the scalp.

4.....The new foam has "Years of extensive research" behind it and "clinical trials with more than 300 test subjects"

I just wanted to emhasise point 1 above to show that the new foam, according to Rogaines manufacturers (not me), IS more effective at growing hair - 65.88% more effective than the original version at the 16 week point.

Unfortunately, we don't have any hair counts to compare as yet as the new FDA study for the Rogaine Foam isn't out yet. All we have to go on,currently, are the comments above,as supplied by the manufacturers above which clearly suggest the new Foam is significantly better at growing hair.

So its not just "cosmetically" better. It grows alot more hair, is far easier to apply, looks good and has the advantage of lower side efftcs such as red/puffy face and the usual scalp problems caused by the high PG content.

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http://www.rogaine.com/Results/?ID=1688

Men’s Rogaine Foam has Been Proven Effective

Years of extensive research were conducted resulting in the following conclusions:

A survey was done among hundreds of men which found that Men’s Rogaine Foam was overwhelmingly preferred vs Rogaine solution.

The new foam formulation was shown to be safe, well tolerated, and effective when used as directed

Clinical trials with more than 300 test subjects were conducted to determine the effectiveness of Men’s Rogaine Foam

Results From a 16-Week Study

Researchers compared twice-daily application of 5% Men’s Rogaine Foam with twice-daily application of a placebo (medication-free solution) over 16 weeks in men with hereditary hair loss.

The results showed that 85% of men regrew hair in just 16 weeks.

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In the official Rogaine 5% extra strength formula clinical trials that were submitted by Upjohn to the FDA , the following 16 week results were obtained (with the 32 week results in brackets):

Rogaine 5% extra strength formula

No growth..................44%...(14%)

Minimal Growth.........49%...(46%)

Moderate Growth.......04%...(38%)

Dense Growth............03%...(03%)

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The new foam minox was developed in conjunction with a company called Connetics.

http://www.connetics.com/2002/products/dermatology.html

"We have granted Pfizer rights to our proprietary foam delivery technology for use with Pfizer’s Rogaine® hair loss treatment."

US Patent Number 6,946,120 http://patft.uspto.gov

"Many of the formulations require (or would require where the amount of minoxidil is greater than 5%) a very high percentage (often in the range of 30 to 50%) of propylene glycol or a similar glycol product in order to improve the solubility of minoxidil. Due to the viscosity and tack of propylene glycol, large amounts of propylene glycol or similar agents in a composition are not pharmaceutically or cosmetically elegant and may be unacceptable to the consumer. In addition, high concentrations of propylene glycol may cause local irritation and hypersensitivity upon application to the scalp.

It would accordingly be a significant advance in the art if a composition could be provided which would permit the inclusion of an increased percentage of the active ingredient, but without the disadvantages associated with a high propylene glycol concentration."

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If you have lost your receipt, do what i did, just take a digital photo and email it to them. They will send you new bottles of the NEW formula containing the Adenosine & Procyanidin. These new bottles have a Serial Number beginning with "S" as opposed to the original bottles beginning with "A".

Their customer service is first rate.

Spectral DNC recall

DS Laboratories has identified a problem with a batch of Spectral DNC Hair Loss Treatment. The spray pump on Spectral DNC can cause the spray to clog and make it difficult or impossible to dispense the contents of the bottle.

We deeply regret any inconvenience caused to our customers by this problem. If you have purchased Spectral DNC with a serial number between A00112479 and A00126979 we ask that you please contact us to request a replacement bottle that will be dispatched immediately free of charge. To request a replacement bottle of Spectral DNC Hair Loss Treatment please email recall@divineskin.com with the serial number of the bottle you have purchased, where you have purchased it, and the address where a replacement can be sent. You can also request a replacement by phone at 516-620-0874.

www.ebay.com - $29.99 for Rogaine foam 3-pack

www.dermadoctor.com (USA) - $39.08 for Rogaine foam 3-pack

www.drugstore.com - $39.09 for Rogaine foam 3-pack

www.rogainedirect.com (official Rogaine site) - $53.95 for a 4 month supply

NOTE: You can also buy $5 + $10 off Rogaine foam coupons from EBAY (USA)

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SPECTRAL DNC

$35.99 pretty much everywhere.

SPECTRAL RS

$33.50 pretty much everywhere.

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anyone get it any cheaper online ? if so, please post link + price.

I have been using Minox. along my hairline now for 7 months and have seen ZERO results (3 months Nanosal 3.3% & 4 months Spectral DNC).

Needless to say, with all the positive coments about Spectral DNC, including the 48 at http://www.folica.com/Spectral_DNC_r1942_1.html

i was extremely disillusioned with Spectral DNC to say the least and was just about to switch to Rogaine Foam/Scalpmed. However, a poster made an interesting comment yesterday saying that he has tried all 3 versions of DNC, the original yellow version, the recall version and the new "s" version. He saw results with both the original and "s" version...but NO results with the recall version !

We already know they got the formula wrong for the recall version (hence the recall as the formula was clogging the nozzles). so its quite possible that this could be the reason for my total lack of results on 4 months of DNC along my hairline. All 6 of my bottles were the recall version and my new "s" bottles should be here very shortly.

So if you are using the recall version, try replacing them with the new "s" version first before binning DNC altogether.

Here was his post yesterday:

debris, (thanks again "debris") Saturday November 25, 2006 11:51 AM

I am seeing results in my hairline. Spectral was the first thing that showed me that there is possibility of regrowth there. anyway. I use it several months now (I think I'll be starting my 6th soon). And I have noticed dramatic difference between various batches of spectral. First two and half months I was on the very old saturated yellow spectral. it gave me long vellous hair in temples, and by the end of the second month they started to be pigmented. very good result imho.

then i used for one and half month newer spectral, that was not so yellowish, it was yellow-orange one. BTW it was from the famous A0 batch that there was that official recall for.

anyway, it gave me horrible itch. and I was determined to get the old one from somewhere as it didn't carry on the improvement so quickly as the first yellow one. I had one old bottle of the yellow one, so I switched to it, itch slowly subsided, temples started improved in just one month once again.

now i am using the very new S spectral. absolutely no itching, very quickly dries out, no colouring of skin. best results so far. but I must admit that for the last 2 months I am also using flutamide. and recently I added retin-a + hydrocortisone.

anyway I like the latest spectral most. I still use dropper as it is the best delivery system directly to the skin. And sprayer would be quite waste imho.

red rose Saturday November 25, 2006

Spectral DNC is the best minoxidil I have ever used.

24 months of Kirland 5% Minoxidil - nothing

6 months of Spectral DNC - general thickening to the point that I don't even need to use concealer any more.

What an awesome product.

http://www.folica.com/Spectral_DNC_r1942_1.html

Its on their website (top left) at: http://www.divineskin.com

Revita® high-performance hair growth stimulating shampoo

DS Laboratories has developed a revolutionary shampoo designed to control hair loss and stimulate hair growth. Revita® will go on sale in stores this November in North America and will hit stores internationally by the end of the year.

Pimary ingredients:

Apple Polyphenol

Copper Peptides

Spin Traps

Ketoconazole 2%

Caffeine 4%

MSM

Biotin

Emu Oil

Rooibos Tea

Carnitine Tartrate

Amino Acids: Ornitine, Taurine, Cysteine,

Technology

Revita®, the most efficient hair growth stimulating shampoo available on the market is the final result of DS Laboratories efforts on cutting edge research. Revita® is a powerful and unique combination of active ingredients specially designed to maintain scalp vitality and act on follicle dysfunctions in order to achieve the best results in short periods of time.

Performance

Revita® is the only shampoo product that combines specific anti-DHT action with antioxidant and antiflamatory effects. Revita® associates hair growth stimulating effect with powerful moisturizing properties, and provides basic amino acid supply offering significant tensile benefits to the hair shaft. This complete mechanism of action of Revita® offers unique and powerful results on scalp vitality and hair growth stimulation. Revita® increases the diameter of the hair strand while gently cleansing the scalp, leaving the hair soft with a pleasant smell. Revita® acts since the beginning, before the problem appears, until later phases of hair loss.